Vacation with Derek follows the McDonald-Venturi family as they spend their summer vacation at their grandmother's lodge. Sibling rivalry between Derek and Casey escalates when they meet new love interests, Jesse and Roxy respectively. However, their idyllic getaway takes a turn when Roxy's father plans to destroy the natural beauty surrounding the lodge. The McDonald-Venturi kids must unite to save both the lake and the lodge in this heartwarming comedy.